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selective mc4r antagonist  (Millipore)

 
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    Structured Review

    Millipore selective mc4r antagonist
    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
    Selective Mc4r Antagonist, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective mc4r antagonist/product/Millipore
    Average 90 stars, based on 1 article reviews
    selective mc4r antagonist - by Bioz Stars, 2026-04
    90/100 stars

    Images

    1) Product Images from "Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling"

    Article Title: Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

    Journal: bioRxiv

    doi: 10.1101/2022.11.28.518266

    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to MC4R antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
    Figure Legend Snippet: (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to MC4R antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .

    Techniques Used: Imaging, Injection



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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to <t>MC4R</t> antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .
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    Image Search Results


    (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to MC4R antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .

    Journal: bioRxiv

    Article Title: Proopiomelanocortin (POMC) is a negative regulator of tadpole aggression through opioid receptor signaling

    doi: 10.1101/2022.11.28.518266

    Figure Lengend Snippet: (A) POMC is enriched in the diencephalon of aggressive tadpoles. Plot shows statistical significance plotted against magnitude of change. (B) There is a significant difference between POMC-pS6 positive cells in the preoptic area of the hypothalamus (POA) of aggressive and control animals. (C) Fluorescent imaging of POMC (magenta), pS6-positive cells (green) and their colocalization (white) in the POA; scale bar is 50 μm. (D) Schematic of experimental injection protocol. Treatment with naltrexone increased the number of attacks compared to MC4R antagonist and vehicle treated animals (E) and total aggressive actions compared to ACTH, MC4R antagonist, and vehicle treated animals (F) .

    Article Snippet: A dose-response curve was performed for a selective MC4R antagonist, M4603 (Sigma Aldrich, #SHU9119), which binds aMSH.

    Techniques: Imaging, Injection